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TRAVATAN Z® Solution prescription.

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IMPORTANT SAFETY INFORMATION: TRAVATAN Z^® solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are intolerant of other IOP-lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another IOP-lowering medication. TRAVATAN Z^® solution is contraindicated in patients with known hypersensitivity to travoprost or any other ingredients in this product. Prostaglandin analogues, including travoprost ophthalmic solution, 0.004%, have been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris and periorbital tissue (eyelid) and increased pigmentation and growth of eyelashes. These changes may be permanent. TRAVATAN Z^® solution may gradually change eye color, increasing the amount of brown pigmentation in the iris by increasing the number of melanosomes (pigment granules) in melanocytes. The long term effects on the melanocytes and the consequences of potential injury to the melanocytes and/or deposition of pigment granules to other areas of the eye are currently unknown. The most common adverse event observed in studies with TRAVATAN^® solution and TRAVATAN Z^® solution was ocular hyperemia which was reported in 30 to 50 percent of patients. Ocular events reported at an incidence of 5 to 10 percent included decreased visual acuity, eye discomfort, foreign body sensation, pain and pruritus. The recommended dosage is one drop in the affected eye(s) once daily in the evening. Before using TRAVATAN Z^® solution, please read the full prescribing information.